A fast method for in vitro biomineralization of PVA/alginate/biphasic calcium phosphate hydrogel
نویسندگان
چکیده
• Porous BPS hydrogel was fabricated. fast biomineralized using urease. The bone-like apatite formed on hydrogels. cytocompatibility of biomimeralized hydrogels improved. development with excellent is great importance for tissue engineering applications. Here, porous polyvinyl alcohol/alginate/biphasic calcium phosphate (BPS) were fabricated via chemical and physical crosslinking methods, the in vitro urease saturated calcium-phosphorus solution. For comparison, also treated simulated body fluid (SBF) Dulbecco’s modified Eagle’s medium fetal bovine serum (DMEM-FBS), respectively. physicochemical characterizations confirmed that quickly urease-biomineralized compared to SBF DMEM-FBS Additionally, bone marrow derived mesenchymal stem cells (BMSCs), adhered proliferated hydrogels, systematically analyzed cell counting kit-8 (CCK-8). This paper demonstrated potential biomineralization improve
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ژورنال
عنوان ژورنال: Materials Letters
سال: 2022
ISSN: ['1873-4979', '0167-577X']
DOI: https://doi.org/10.1016/j.matlet.2021.131182